Efficacy of low-dose 90Sr-90Y therapy combined with topical application of 0.5% timolol maleate solution for the treatment of superficial infantile hemangiomas

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Topical Timolol Maleate Treatment of Infantile Hemangiomas.

BACKGROUND There has been a dramatic increase in the off-label use of ophthalmic timolol maleate, a β-blocker used for infantile hemangioma (IH) treatment as a topical counterpart to oral propranolol. Its safety and efficacy in a pediatric population with IH have not been evaluated in a large cohort. Our goal was to retrospectively assess timolol's effectiveness, discern characteristics associa...

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Evaluation of the efficacy and safety of topical timolol maleate combined with oral propranolol treatment for parotid mixed infantile hemangiomas

The aim of the present study was to assess the efficacy and safety of topical timolol maleate combined with oral propranolol for parotid infantile hemangiomas. Between October 2012 and April 2014, propranolol was administered orally at a dose of 1.0-1.5 mg/kg/day to 22 infants with proliferating hemangiomas in the Department of Oral and Maxillofacial Surgery (Hospital of Stomatology, China Medi...

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Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma

The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs...

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Topical timolol maleate combined with oral propranolol in treatment for nasus externus infantile hemangiomas: a retrospective study of 17 cases

The aim of our study was to assess the efficacy and safety of topical timolol maleate combined with oral propranolol for nasus externus infantile hemangiomas. Between March 2012 and May 2014, propranolol was given orally to 17 infants with proliferating hemangiomas in a dose of 1.0-1.5 mg/kg/day in our department and dipped topically a small amount of 0.5% timolol maleate eye drops with medical...

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RCT of timolol maleate gel for superficial infantile hemangiomas in 5- to 24-week-olds.

OBJECTIVE Timolol maleate 0.5% gel is a safe and effective medication for treating superficial infantile hemangiomas (IHs) in infants with a median age of 9 weeks. METHODS Forty-one infants who had superficial IHs without ulceration and not near mucosal surfaces were recruited and randomly assigned to placebo and treatment (timolol maleate 0.5% gel) groups. Efficacy was assessed by performing...

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ژورنال

عنوان ژورنال: Experimental and Therapeutic Medicine

سال: 2015

ISSN: 1792-0981,1792-1015

DOI: 10.3892/etm.2015.2609